(2,3,4,5a,12,19a)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic Acid Methyl Ester
Vindoline
CAS: 2182-14-1
Molecular Formula: C25H32N2O6
(2,3,4,5a,12,19a)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic Acid Methyl Ester - Names and Identifiers
(2,3,4,5a,12,19a)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic Acid Methyl Ester - Physico-chemical Properties
| Molecular Formula | C25H32N2O6 |
| Molar Mass | 456.53 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | 163-1650C |
| Boling Point | 569.8±50.0 °C(Predicted) |
| Specific Rotation(α) | D20 -18° (chloroform); D27 +42° (chloroform) |
| Flash Point | 298.421°C |
| Solubility | Soluble in methanol, DMSO and other solvents, insoluble in petroleum ether. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White crystal |
| Color | White to Off-White |
| pKa | 5.5 in 66% DMF (Moza, Trojánek) |
| Storage Condition | -20°C Freezer |
| Refractive Index | 1.626 |
| MDL | MFCD27991347 |
| Physical and Chemical Properties | Soluble in methanol, ethanol, DMSO and other organic solvents, derived from Catharanthus roseus. |
(2,3,4,5a,12,19a)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic Acid Methyl Ester - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 68 - Possible risk of irreversible effects |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. |
| HS Code | 29339900 |
(2,3,4,5a,12,19a)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic Acid Methyl Ester - Reference
| Reference Show more | 1. Bai Daoming, Zhou Guangtao, Dai Long. Optimization of Process for Purification of Catharanthus roseus Chinese Duoling and Vinblastine by Cation Exchange Resin [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2012, 014(012):182-184. 2. [IF = 5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum." Front Microbiol. 2015 Dec;0:1466 3. [IF = 6.268] Liu Tengfei et al."Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae." Commun Biol. 2021 Sep;4(1):1-9 4. [IF = 5.118] Wenzhu Tang et al."Enhancement of Vindoline and Catharanthine Accumulation, Antioxidant Enzymes Activities, and Gene Expression Levels in Catharanthus roseus Leaves by Chitooligosaccharides Elicitation." Mar Drugs. 2022 Mar;20(3):188 |
(2,3,4,5a,12,19a)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic Acid Methyl Ester - Reference Information
| biological activity | Vindoline is a periwinkle alkaloid extracted from Catharanthus roseus leaves, which has a weak inhibitory effect on the self-assembly of tubulin (tubulin) effect. |
| chemical properties | soluble in methanol, ethanol, DMSO and other organic solvents, derived from periwinkle. |
| use | vendoling has antibacterial, anti-inflammatory and anti-cancer effects. A monomer vinblastine that exhibits anti-mitotic activity by inhibiting the assembly of microtubules. |
Last Update：2024-04-09 20:52:54
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Product Name: Vindoline Visit Supplier Webpage Request for quotationCAS: 2182-14-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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